• 13-Type HPV DNA Test versus 5-Type HPV mRNA Test in Triage of Women Aged 25–33 Years with Minor Cytological Abnormalities–6 Years of Follow-Up 

      Rad, Amir; Sørbye, Sveinung; Brenn, Tormod; Tiwari, Sweta; Løchen, Maja-Lisa; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-25)
      Background: A specific, cost-effective triage test for minor cytological abnormalities is essential for cervical cancer screening among younger women to reduce overmanagement and unnecessary healthcare utilization. We compared the triage performance of one 13-type human papillomavirus (HPV) DNA test and one 5-type HPV mRNA test. Methods: We included 4115 women aged 25–33 years with a screening ...
    • Achievements of primary prevention targets in individuals with high risk of cardiovascular disease: an 8-year follow-up of the Tromsø study 

      Hagen, Amalie Nilsen; Ariansen, Inger Kristine Holtermann; Hanssen, Tove Aminda; Lappegård, Knut Tore; Eggen, Anne Elise; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)
      Aims To study change over 8 years in cardiovascular risk, achievement of national guideline-based treatment targets of lipids, blood pressure (BP) and smoking in primary prevention of cardiovascular disease (CVD), medication use, and characteristics associated with target achievement among individuals with high CVD risk in a general population.<p> <p>Methods and results We followed 2524 women ...
    • Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study 

      Iversen, Birgitte; Jacobsen, Bjarne Koster; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 ...
    • Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium 

      Morseth, Bente; Geelhoed, Bastiaan; Linneberg, Allan; Johansson, Lars; Kuulasmaa, Kari; Salomaa, Veikko; Iacoviello, Licia; Constanzo, Simona; Söderberg, Stefan; Niiranen, Teemu; Vishram, Julie K.K.; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Zeller, Tanja; Blankenberg, Stefan; Ojeda, Francisco; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      <p><i>Background:</i> The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age. <p><i>Methods:</i> We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from ...
    • Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes 

      Csengeri, Dora; Sprünker, Ngoc-Anh; Di Castelnuovo, Augusto F; Niiranen, Teemu; Vishram-Nielsen, Julie K.K.; Costanzo, Simona; Soderberg, Stefan; Jensen, Steen M; Vartiainen, Erkki; Donati, Maria Benedetta; Magnussen, Christina; Camen, Stephan; Gianfagna, Francesco; Løchen, Maja-Lisa; Kee, Frank; Kontto, Jukka; Mathiesen, Ellisiv B.; Koenig, Wolfgang; Blankenberg, Stefan; de Gaetano, Giovanni; Jørgensen, Torben; Kuulasmaa, Kari; Zeller, Tanja; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
      Aims<p> <p>There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.<p> <p>Methods and results <p> In a community-based pooled cohort, we followed 107 845 individuals for the ...
    • The ambiguity of physical activity, exercise and atrial fibrillation 

      Morseth, Bente; Løchen, Maja-Lisa; Ariansen, Inger Kristine Holtermann; Myrstad, Marius; Thelle, Dag Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)
      Although commonly associated with cardiovascular disease or other medical conditions, atrial fibrillation may also occur in individuals without any known underlying conditions. This manifestation of atrial fibrillation has been linked to extensive and long-term exercise, as prolonged endurance exercise has shown to increase prevalence and risk of atrial fibrillation. In contrast, more modest physical ...
    • Antidepressant use and risk of myocardial infarction A longitudinal investigation of sex-specific associations in the HUNT study 

      Karlsen, Håvard Rudi; Løchen, Maja-Lisa; Langvik, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01)
      Objective - Antidepressants are thought to affect the risk of cardiovascular disease, although the nature of the association is unclear. Men and women have unique cardiovascular risk factors, and sex differences in depression as well as the efficacy of antidepressants are important to consider. We examined whether antidepressant use was associated with risk of having a myocardial infarction (MI) and ...
    • Assessment of mental health trajectories before and after myocardial infarction, atrial fibrillation or stroke: analysis of a cohort study in Tromsø, Norway (Tromsø Study, 1994-2016) 

      Lorem, Geir F; Opdal, Ida Marie; Wilsgaard, Tom; Schirmer, Henrik; Løchen, Maja-Lisa; Olsen, Ingrid Petrikke; Steigen, Terje; Rognmo, Kamilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Objectives - The increased survival rate of cardiovascular disease (CVD) implies a higher proportion of individuals who live with CVD. Using data from the Tromsø Study, we aimed to investigate mental health symptom trajectories before and after myocardial infarction, atrial fibrillation or stroke in a general population and to explore factors that contribute to the association.<p> <p>Design - ...
    • Association between diastolic dysfunction and future atrial fibrillation in the Tromsø Study from 1994 to 2010 

      Tiwari, Sweta; Schirmer, Henrik; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Heggelund, Geir; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-13)
      Objective. To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods. We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. ...
    • Association between espresso coffee and serum total cholesterol: the Tromsø Study 2015-2016 

      Svatun, Åsne Lirhus; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-10)
      Background - Coffee raises serum cholesterol because of its diterpenes, cafestol and kahweol, and the effect varies by brewing method. Population-based research on espresso coffee’s impact on serum cholesterol is scarce. Our aim was to examine how various brewing methods, in particular espresso, were associated with serum total cholesterol (S-TC).<p> <p>Methods - We used cross-sectional population ...
    • Association of fatal myocardial infarction with past level of physical activity: a pooled analysis of cohort studies 

      Hansen, Kim Wadt; Peytz, Nina; Blokstra, Anneke; Bojesen, Stig E.; Celis-Morales, Carlos; Chrysohoou, Christina; Clays, Els; De Bacquer, Dirk; Galatius, Søren; Gray, Stuart R.; Ho, Frederick; Kavousi, Maryam; Koolhaas, Chantal M.; Kouvari, Matina; Løchen, Maja-Lisa; Marques-Vidal, Pedro; Osler, Merete; Panagiotakos, Demosthenes; Pell, Jill P.; Sulo, Gerhard; Tell, Grethe Seppola; Vassiliou, Vassilios; Verschuren, W.M. Monique; Prescott, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-10)
      <p>Aims: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies. <p>Methods and results: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients ...
    • Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015 

      Løchen, Maja-Lisa; Gram, Inger Torhild; Mannsverk, Jan T.; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Objectives: <br> There is a shift in the smoking population from daily smokers to light or occasional smokers. The knowledge about possible adverse health effects of this new smoking pattern is limited. We investigated smoking habits with focus on occasional smoking in relation to total mortality in a follow-up study of a Norwegian general population. <br> Setting: <br> A population study ...
    • Associations between physical activity, left atrial size and incident atrial fibrillation: the Tromsø Study 1994–2016 

      Heitmann, Kim Arne; Løchen, Maja-Lisa; Stylidis, Michael; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)
      Aims: Left atrial (LA) enlargement is an independent risk factor for atrial fibrillation (AF). Interestingly, some athletes have increased risk of AF, which may be linked to LA enlargement; however, little is known about the relationship between LA enlargement and AF risk at moderate-level physical activity (PA). We aimed to explore the associations between PA, LA size and risk of incident ...
    • Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...
    • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

      Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
      <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
    • Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study 

      Enga, Kristin Fjeldstad; Rye Holmboe, Ina; Mathisen Hald, Erin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Atrial fibrillation in female endurance athletes 

      Myrstad, Marius; Johansen, Kristoffer Robin; Sørensen, Eivind; Løchen, Maja-Lisa; Hylen Ranhoff, Anette; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
    • Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study 

      Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Arntzen, Kjell Arne; Ball, Jocasta; Stewart, Simon; Wilsgaard, Tom; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
      Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...